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Organelle redox control and protein maturation.
The Liu Lab studies how organelles move, buffer and sense glutathione, with a focus on SLC33A1-mediated oxidized glutathione export from the endoplasmic reticulum.
- SLC33A1
- ER GSSG export
- GSSG:GSH
- Redox balance
- ERAD / UPR
- Proteostasis outcomes
ER-IP platform
Rapid ER immunopurification turns organelles into measurable samples.
The SLC33A1 paper builds from an ER immunopurification workflow that isolates ER material quickly enough for compartment-focused metabolomics, proteomics and genetic discovery. These lab-provided microscopy images show ER pulldown bead samples used as visual source material for the platform story.
Research program
Discovery systems for compartment-specific metabolism.
Shanshan's program sketches clarify the broader direction: connect ER protein homeostasis to metabolite homeostasis, use genetics to discover transport and regulation, and extend ER-tagging into tissue and disease contexts.
SLC33A1 mechanism
From ER-IP to transporters.
The flagship paper connects a method, a genetic hit, direct transport activity, structural mechanism and cellular stress phenotypes. The rotating video runs beside the sequence as a compact visual anchor.
Publications
Selected publications.
The SLC33A1 paper is PDF-verified locally. The full publication list should still be reconciled against Scholar, ORCID, PubMed or a CV export.
People
A PI-centered launch page that can grow cleanly.
Join us
Join a new lab studying organelle metabolism and redox stress.
Our lab welcomes applications from research assistants, postdoctoral fellows, graduate students, and summer students. Interested candidates should email shanshan.liu@yale.edu with a CV and a brief description of their research interests.
News
Lab updates.
Contact
For applicants, collaborators and funders.
Add the confirmed Yale email, department, building and profile links when available. This independent site does not use Yale logos or imply official Yale ownership.